Acute coronary syndrome
Conditions
Interventions
Sponsors
First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years; 2. Coronary angiography confirmed that at least one coronary artery had a stenosis degree> 50%; 3. At least one troponin increase or decrease value> 99% of the upper limit of the reference value, accompanied by at least one of the following: (1) Symptoms of ischemia; (2) New ST segment and T wave changes or ECG showing new left bundle branch block; (3) ECG shows pathological Q wave progression; (4) Evidence of radiological evidence of reduced myocardial contraction or abnormal wall contraction; 4. Loaded dual antiplatelet drugs (ASA 300mg + clopidogrel 300mg) have been given before PCI.
Exclusion criteria
Exclusion criteria: 1. Complicated with severe heart valve disease; 2. Combined with severe congenital heart disease; 3. Combined with hyperdynamic heart disease such as hyperthyroidism and anemia; 4. Complicated with pulmonary heart disease; 5. Hypertrophic obstructive cardiomyopathy; 6. Severe hypotension (SBP 160mmHg, and / or DBP> 100mmHg before PCI); 8. Hepatic insufficiency (defined as ALT or total bilirubin greater than 3 times the upper limit of normal); 9. Renal insufficiency (defined as blood creatinine greater than 1.5 times the upper limit of normal); 10. Patients at high risk of bleeding, such as thrombocytopenia, hematological diseases, etc.; 11. Active peptic ulcer and skin ulcer; 12. Patients allergic to clopidogrel, ticagrelor, and aspirin; 13. Patients with a history of cardiogenic shock within two weeks; 14. Pregnant and lactating women, women of childbearing age who cannot be strictly contraceptive during treatment; 15. Those without legal capacity or limited legal capacity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause death and cardiac death;SEN, SPE, ACC, AUC of ROC; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stroke, bleeding events above BARC level 2, readmission and major cardiac adverse events (MACE) include: all-cause death, stent thrombosis, cardiogenic death, target vessel reconstruction, and stent thrombosis.; | — |
Countries
China
Contacts
Public ContactXiang Xie
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed