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Screening of plasma exosome miRNA and its mechanism for diagnosis of perioperative neurocognitive dysfunction

Screening of plasma exosome miRNA and its mechanism for diagnosis of perioperative neurocognitive dysfunction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900028557
Enrollment
Unknown
Registered
2019-12-27
Start date
2020-07-24
Completion date
Unknown
Last updated
2020-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PND

Interventions

Gold Standard:Peripheral blood sample, exosomal RNA?miRNA was extracted by the polysommer method
Index test:GDNF&#32
detecting&#32
by&#32
ELISA miRNA&#32
qRT-PCR

Sponsors

the affiliated Hosipital of Southwest Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. more than 65 years old; 2. A hip replacement will be planned(or valve replacement surgery under CPB, Nonstop coroonary artery bypass grafting)

Exclusion criteria

Exclusion criteria: 1. Preoperative simple mental state checklist score < 24; 2. History of mental or nervous system problems, severe hearing or visual impairment; 3. Interrupt the experimenter; 4. Unable to communicate with visitors.

Design outcomes

Primary

MeasureTime frame
exsomal microRNA;GDNF;SEN, SPE, ACC, AUC of ROC;—

Countries

China

Contacts

Public ContactDuan Xiaoxia

the Affiliated Hosipital of Southwest Medical University

782348971@qq.com+86 13568635458

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026