Major Depressive Disorder
Conditions
Interventions
Control Group:Treat with the escitalopram
Experimental group:Treat with aripiprazole and escitalopram
Sponsors
Shandong Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for DSM-5 'major depressive disorder'; 2. Patients with first episode of major depressive disorder who have not received any treatment, or have not received any treatment in the last 2 months; 3. Han nationality, 18-45 years old, regardless of gender; 4. Aged of first onset >=18 years; 5. Hamilton Depression Scale (HAMD-17) >=17, mood disorder questionnaire (MDQ) <7; 6. Junior high school or above; 7. Participate in this study voluntarily and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. A history of serious physical diseases, organic brain diseases and craniocerebral trauma; 2. Patients with psychotic symptoms or other mental disorders; 3. Serious suicide and nssi risk and behavior; 4. No cooperation or inability to effectively complete the experimenter in the research process; 5. Persons known to be allergic to the ingredients of research drugs; 6. Family history of bipolar disorder; 7. Those who are currently in the perinatal period or have a pregnancy plan; 8. Patients who intend to receive MECT during treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum prolactin levels;Hamilton Depression Scale;Hamilton Anxiety Scale;Mood Disorder Questionnaire;Thinc-it;Wsiconsin Card Sorting Test;Continuous Perfomance Test;Rating Scale for extrapyramidal Side Effects;Liver function;Blood glucose;Blood lipids; | — |
Countries
China
Contacts
Public ContactGuanglei XUN
Shandong Mental Health Center
Outcome results
None listed