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L-arginine supplementation for prevention of acute altitude hypoxia response and immunosuppression: a multi-center, Randomized, Double-blind, Controlled, Trial

L-arginine supplementation for prevention of acute altitude hypoxia response and immunosuppression: a multi-center, Randomized, Double-blind, Controlled, Trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900028500
Enrollment
Unknown
Registered
2019-12-23
Start date
2020-03-01
Completion date
Unknown
Last updated
2020-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute hypoxia response

Interventions

LS: experimental group:L-Arginine supplementation
LS: control group:placebo supplementation
XA: experimental group:L-Arginine supplementation
XA: Control group:palcebo supplementataion

Sponsors

The School of Military Preventive Medicine of Air Force Medical University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
17 Years to 22 Years

Inclusion criteria

Inclusion criteria: 1. Healthy young people aged 17-22, who are newly admitted to Lhasa / Xi'an (over 1 month in a row), 2. normal liver and kidney function, 3. no organic disease;

Exclusion criteria

Exclusion criteria: 1. Recent (within 12 month) history of entering the plateau or altitude pre-adaptation intervention; 2. Recent (within 1 month) history of vaccination; 3. Recent (within 1 month) history of acute illness (blood, immune, infectious, skin and other diseases); 4. Mental or neurological disease history; 5. related drug allergies history or cannot use the drug for other reasons; 6. poor compliance exists a serious disease; 7. other circumstances not suitable for participation in the trial.

Design outcomes

Primary

MeasureTime frame
Routine blood test;Peripheral blood mononuclear cell population;Basic physiological index;Body composition index;Lake Louise Score, LLS;Incidence of conventional infectious diseases;

Countries

China

Contacts

Public ContactWenjing Luo

The School of Military Preventive Medicine of Air Force Medical University

luowenj@fmmu.edu.cn+86 029 84774863

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026