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A multicenter, prospective, randomized, controlled trial for Neoadjuvant Chemotherapy plus Concurrent Chemoradiotherapy Versus Concurrent Chemoradiotherapy alone in Locally Advanced Cervical Cancer

A multicenter, prospective, randomized, controlled trial for Neoadjuvant Chemotherapy plus Concurrent Chemoradiotherapy Versus Concurrent Chemoradiotherapy alone in Locally Advanced Cervical Cancer

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900028493
Enrollment
Unknown
Registered
2019-12-23
Start date
2018-01-01
Completion date
Unknown
Last updated
2020-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cervical cancer

Interventions

Group 2:Neoadjuvant Chemotherapy plus Concurrent Chemoradiotherapy
Group 1:Concurrent Chemoradiotherapy alone

Sponsors

The Fourth Affiliated Hospital of Guangxi Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Locally advanced cervical cancer with pathological diagnosis (stage IB2, IIA2, IIB-IVA); 2. Aged 18 to 65 years; 3. PS score 0-1; 4. Estimated survival time is greater than 6 months; 5. Organ functions: white blood cells >=4.0*10^9/L, neutrophils >=1.5*10^9/L; platelets >=100*10^9/L; hemoglobin >=100g/L; Liver function AST and ALT and bilirubin = 60 ml/min.; 6. Can understand the study and has signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Have severe comorbidities or basic diseases; 2. Combine with other malignant tumors; 3. Pregnant women, lactating women; 4. The patient has physical or mental illness, or has no civil capacity or limited capacity for civil conduct.

Design outcomes

Primary

MeasureTime frame
OS;PFS;

Secondary

MeasureTime frame
AE;ORR;LCR;DMFS;

Countries

China

Contacts

Public ContactCHEN Shaojun

The Fourth Affiliated Hospital of Guangxi Medical University

138772962623@163.com+86 138772962623

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026