acute necrotizing encephalopathy
Conditions
Interventions
Group 1:Plasma exchange + high doses of methylprednisolone + immunoglobulin
Group 2:high doses of methylprednisolone + immunoglobulin
Sponsors
The PICU of Beijing Children's Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged 1 month to 18 year old; 2. Admitted to hospital within 24h; 3. Conform to the diagnostic criteria of acute necrotizing encephalopathy.
Exclusion criteria
Exclusion criteria: 1. Glasgow score 2T; 2. Children with severe hypersensitivity to one of the three components of methylprednisolone, immunoglobulin and plasma; 3. Children with essential hypertension, primary immunodeficiency, genetic metabolic disease and other basal diseases; 4. Within 24 hours after admission, children with acute necrotizing encephalopathy whose parents request to give up treatment or transfer to other hospital due to various reasons such as economy and prognosis (Children dying from disease are not included); 5. Parents do not agree to use high doses of methylprednisolone, immunoglobulin, and plasmapheresis for any one or more treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Discharge fatality rate;length of stay in PICU;Invasive mechanical ventilation time;length of stay;Neurological sequelae; | — |
Countries
China
Contacts
Public ContactQian Suyun
Beijing Children's Hospital affiliated to Capital Medical University
Outcome results
None listed