Uric acid nephropathy/Hyperuricemia
Conditions
Interventions
Experimental group:High colon dialysis + Retention enema of 'Yiqing Fang'
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnostic criteria: meet the diagnostic criteria for hyperuricemia and uric acid nephropathy [5-6]; 2. Patients with chronic kidney disease [7] (CKD) stage 1-4; 3. Aged >= 16 years and <= 78 years; 4. Patients who accept this study and agree to sign the informed consent form, who can cooperate on time; 5. TCM syndrome classification and quantification basis: refer to 'Guidelines for Clinical Research of New Chinese Medicines' [8], 'Diagnosis, Syndrome Differentiation and Efficacy Determination of Uric Acid Nephropathy' designated by the Nephrology Branch of Chinese Traditional Chinese Medicine Association in 2008, Belong to spleen-kidney qi deficiency, liver-kidney yin deficiency, qi-yin deficiency, concurrent wet turbidity, and blood stasis syndrome[6]; 6. Those who did not use traditional Chinese medicine or western medicine to lower uric acid in the 2 weeks before the test, or those who used related drugs but stopped for more than 2 weeks to wash out; 7. Long-term use of hydrochlorothiazide and other drugs that have an effect on blood uric acid, and can replace other drugs, a 2-week washout period after stopping and changing the drug;
Exclusion criteria
Exclusion criteria: 1. TCM syndrome differentiation is those with deficiency of spleen and kidney yang and deficiency of both yin and yang; 2. Taking other drugs that affect kidney function; 3. Patients with acute severe infection lesions; 4. Patients with severe colorectal diseases such as hemorrhoids and anal fistula; 5. Combined with serious primary diseases such as heart, kidney, liver, brain, hematopoietic system, and in acute exacerbation; 6. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood urea nitrogen;Serum creatinine;cystatin C;glomerular filtration rate;Uric acid;C-reactive protein;TNF-alpha;24 hour urine protein quantification;Homocysteine;Blood routine;Urine routine;IL-2;IL-4;IL-6;IL-10;IFN-y; | — |
Secondary
| Measure | Time frame |
|---|---|
| N-acetyl-beta-D-glucosidase;Urine osmotic pressure; | — |
Countries
China
Contacts
Public ContactZhou Jin
Shenzhen Second People's Hospital
Outcome results
None listed