Refractory epilepsy in children
Conditions
Interventions
Observation group:Treatment with conventional antiepileptic drugs with a ketogenic diet
Control group:Adopt the ordinary traditional diet in combination with conventional antiepileptic drugs.
Sponsors
Second Affiliated Hospital of Army Military Medical University
Eligibility
Sex/Gender
All
Age
0.5 Years to 10 Years
Inclusion criteria
Inclusion criteria: a. All children who do not meet criteria of surgery but meet the diagnotic criteria for refractory epilepsy (ILAE2010) b. Have not tried ketogenic diet before c. Age between six-month and ten years old d. Frequency of seizure more than four times per month e. Guardians agree with the treatment and sign on informed consent
Exclusion criteria
Exclusion criteria: a. Have fatty metabolic liver disease and other metabolic diseases; b. have fever or infection; c. KD treatment contraindications: diseases that interfere with glucose and fat metabolism, or metabolic diseases of the liver (diabetes, carnitine deficiency, mitochondrial enzyme deficiency, ketogenic hypoglycemia, etc.); d. Exclude patients with serious diseases of digestive system, cardiovascular system, respiratory system and urinary system and immune deficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizure Frequency;EEG; | — |
Secondary
| Measure | Time frame |
|---|---|
| GESELL development schedules;ACHENBACH child behavior checklist;Wechsler intelligence scale;infant-youth social life scale;child physical development scale; | — |
Countries
China
Contacts
Public ContactWu Zhifeng
The Second Affiliated Hospital of Army Military Medical University
Outcome results
None listed