Septic shock
Conditions
Interventions
Gold Standard:Clinical outcome: patients with a>=15% increase in CI attributable to the PLR maneuver to be defined as 'volume responders'
Index test:end-expiratory 
pressure 
combined 
with 
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. The diagnostic criteria for septic shock recommended by the diagnostic criteria for Sepsis 3.0, with clinical manifestations of shock and hypoperfusion, and a clear diagnosis of septic shock; 2. aged >=18 years; 3. patients without spontaneous breathing and completely relying on mechanical ventilation; 4. The blood pressure and heart rate fluctuations were less than 10% within 15 minutes before the test, and the hemodynamics was relatively stable.
Exclusion criteria
Exclusion criteria: 1. Primarily judge that those who may die within 24 hours at the end of the disease; 2. Contraindications of volume loading test, such as: obvious volume overload, severe arrhythmia, cardiogenic shock, etc .; 3. unable to use pulse to indicate continuous cardiac output Patients who need to be monitored; 4. Severe patients who need intra-aortic balloon counterpulsation or artificial membrane pulmonary oxygenation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CI;ETCO2;PPV before PLR;CVP;SBP;DBP;MAP;PP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood lactate; | — |
Countries
China
Contacts
Public ContactXiaofen Zhou
Fujian Provincial Hospital
Outcome results
None listed