critical ill
Conditions
Interventions
control group:Fentanyl (0.7-10 µ g / kg / h) analgesia and Propofol (1-4 mg / kg / h) sedation
experimental grou:Butorphanol (10-20 µ g / kg / h) analgesia and Propofol (1-4 mg / kg / h) sedation
Sponsors
Hebei People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) aged >= 18 years, 18kg / m2 = 24h, and the ventilation time was < 48h; 4) sign the informed consent voluntarily and participate in the research.
Exclusion criteria
Exclusion criteria: 1) known allergy to any study drug; 2) for chronic pain of grade 3 or above in the World Health Organization, strong opioids, such as morphine, are often used. Recently, opioids are used for analgesia through spinal cord catheter, epidural or any other regional block; 3) the American Society of anesthesiologists (ASA) classified the fifth grade patients (on the verge of death); 4) nerve injury or brain organic pathological changes; 5) participate in clinical research in the past 30 days; 6) pregnancy or lactation; 7) the researcher thinks it is not suitable to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analgesic score, sedative score,Total dosage of butorphanol; total dosage of fentanyl; total dosage of propofol;; | — |
Secondary
| Measure | Time frame |
|---|---|
| pulling time, ICU stay time, invasive mechanical ventilation time, length of stay, 30 day mortality; | — |
Countries
China
Contacts
Public ContactQuansheng Du
Outcome results
None listed