Non-small cell lung cancer
Conditions
Interventions
None Response Group:Nil
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with stage IV and no brain metastases by Shanghai Pulmonary Hospital after December 2019; 2. NSCLC confirmed by cytology or histology biopsy; 3. No sensitive gene mutations detected by genetic testing EGFR (-), ALK (-), KRAS (-), BRAF (-), ROS1 (-); 4. Aged 18-70 years old; 5. Expected survival time is more than 3 months; 6. ECOG (Eastern Cooperative Oncology Group, ECOG) Physical fitness score is 0 or 1; 7. Hemoglobin in peripheral blood >=100g/L, neutrophil count >=2.0*10^9/L, platelet count >=100*10^9/L.
Exclusion criteria
Exclusion criteria: 1. Severe or uncontrollable systemic diseases; 2. History of tumors (except early cervical cancer, skin basal cell carcinoma, etc.); 3. Patients with difficulty swallowing or gastrointestinal obstruction; 4. Previous History of gastrointestinal surgery; 5. History of inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, or indeterminate colitis; 6. Persistent, infectious gastroenteritis, colitis or gastritis; persistent or chronic diarrhea of unknown etiology; Clostridium difficile infection (relapse) or Helicobacter pylori infection (untreated); 7. Chronic constipation; 8. Use of the following drugs within the last three months: alkali Bismuth salicylate and other similar bismuth basic salicylate drugs; 9. After evaluation, the researcher believes that the study is not good for patients and is not suitable for other conditions in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CR;PR;SD;PD;PFS;OS;Gut microbiome;Fecal metabolomics;Immune factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Compliacation; | — |
Countries
China
Contacts
Public ContactChang Chen
Shanghai Pulmonary Hospital
Outcome results
None listed