postoperative delirium
Conditions
Interventions
Case series:sevoflurane anesthesia
Sponsors
Department of Anesthesiology, Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Aged between 65 and 90 years; (2) Patients with gastrointestinal tumors expected for elective surgery under sevoflurane general anesthesia (2h-6h); (3) ASA Physical Status Classification I-III; (4) Agree to participate in the study voluntarily, and sign the written informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with preoperative history of schizophrenia (including preoperative delirium), and/or taking typical and atypical antipsychotic drugs (Chlorpromazine, Haloperidol, Clozapine, Risperidone, Olanzapine, Quetiapine and extra); (2) Patients with preoperative cognitive dysfunction based on MMSE scale; (3) Severe functional impairment of hearing, vision, and language system; (4) Critically ill (ASA classification IV or above), severe renal dysfunction (requiring of renal replacement therapy), severe hepatic dysfunction (Child-Pugh classification C); (5) Patients planning to enter the ICU after surgery; (6) Identified/suspected of abuse or long-term use of narcotic sedatives or analgesics; (7) Patients with difficult airway that require awake intubation or have been diagnosed with moderate to severe OSAS; (8) Patients with allergies or contraindications to conventional anesthetics; (9) Forehead infections or allergies that not suitable for EEG electrode placement; (10) Patients with a history of general anesthesia within three months; (11) Patients participating in other clinical studies at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within the first 5 postoperative days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of postoperative hospital stay;Hospital mortality;30-day postoperative mortality;Postoperative complications hypothesized to be associated with anesthetic depth (cardiac arrest, myocardial infarction, stroke, incision infection, etc.); | — |
Countries
??
Contacts
Public ContactYing-wei Wang
Huashan Hospital, Fudan University
Outcome results
None listed