dermatomyositis/polymyositis
Conditions
Interventions
Treatment group:Glucocorticoid+Tacrolimus
Control group:Glucocorticoid+Cyclophosphamide
Sponsors
Department of Rheumatology and Immunology, Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Subjects must meet the IIM and/or ADM diagnostic criteria; 2. between 18 and 75 years of age 3. Agree to use effective contraception during the study period (women of child-bearing age); 4. The patient voluntarily participate in the experiment with good compliance, and be able to understand and sign the informed consent before the study; 5. First diagnosis and initial treatment; 6. No immunosuppressive agents or not have received them for >=4 weeks prior to first dose of agent.
Exclusion criteria
Exclusion criteria: 1. merging other rheumatic diseases; 2. merging other diseases that may cause muscle lesions and symptoms of muscle weakness; 3. cancer history; 4. For patients with severe disorders of heart, liver, kidney and other important organs, as well as blood and endocrine system lesions; 5. Those who have received treatment with biological agents within 3 months; 6. Those who are in the period of acute or chronic infection or have a previous history of active tuberculosis; 7. Positive for hepatitis b surface antigen or hepatitis c antibody; 8. Allergy to the test drug or its components; 9. Patients with mental illness or other reasons who cannot cooperate with the treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MDAAT; | — |
Secondary
| Measure | Time frame |
|---|---|
| MDI;chest HRCT; | — |
Countries
China
Contacts
Public ContactWei Wei
Department of Rheumatology and Immunology, Tianjin Medical University General Hospital
Outcome results
None listed