Belching
Conditions
Interventions
Group A:Mosapride tablets (5mg, 3 times / d)
Group B:Mosapride tablets (5mg, 3 times / d), combined with pregabalin (75mg, 3 times / d)
Group C:Pregabalin (75mg, 3 times /d)
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) male or female aged >=17 years old; (2) according to the diagnostic criteria of Roman IV for belching: symptoms should be present for at least 6 months, and the following diagnostic criteria should be met in the past 3 months. It includes excessive upper gastric belching and excessive upper gastric belching; frequent and repeated belching is observed to support upper gastric belching; there is no clear clinical relationship between upper gastric belching; if necessary, intracavitary impedance detection is needed to distinguish upper gastric belching and upper gastric belching; symptoms appear at least 6 months before diagnosis, and meet the above diagnostic criteria in the past 3 months; (3) patients with belching as the first complaint and main symptoms; (4) the subjects understood the whole clinical research process and were able to cooperate with the whole follow-up and efficacy evaluation. (5) It is agreed to take effective contraceptive measures within 3 months from the signing of informed consent to the end of the last trial medication.
Exclusion criteria
Exclusion criteria: 1. Used or allergic to pregabalin within 30 days; 2. Those with gastrointestinal or abdominal operation history within 3 months before screening; 3. Gastroscopic examination found that the gastrointestinal ulcer, tumor, inflammation and other organic lesions; 3. Alcohol addicts; 4. With serious cardiovascular system, liver, respiratory system, urinary system, nervous system, mental system, systemic diseases and immune deficiency diseases, which are not suitable for the researchers; 5. Abnormal laboratory examination which with clinical significance, and the researcher judges that it is not suitable to participate in the study; 6. Planned pregnancy or pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Belching score; | — |
Countries
China
Contacts
Public ContactWei Han
Qilu Hospital of Shandong University
Outcome results
None listed