aneurysmal subarachnoid hemorrhage
Conditions
Interventions
aneurysmal subarachnoid hemorrhage group:None
unruptured aneurysm group:None
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Subjects in the NC group: (1) Right-handed; (2) Patients with unruptured intracranial aneurysms on imaging examination; (3) No neurological, mental illness, no drug abuse or relying on, and no head injury that caused cognitive dysfunction; (4) No abnormalities were observed with conventional brain MRI; (5) Han nationality; (6) Have the ability to complete cognitive function assessment and cooperate with the acquisition of multimodal MRI data, Once every 3 months, 3 consecutive times; (7) Medical history includes negative current medical history, past history, family history, etc. And there are no positive findings that can cause cognitive impairment in the auxiliary examination data such as previous neuroimaging; aSAH subjects are included in the group: (1) Right-handed; (2) Patients with Hunt-Hess grade I-IV aSAH; (3) No history of neurological, psychiatric or drug abuse or dependence, and no head injury leading to cognitive dysfunction in the first 6 months; (4) Conventional brain MRI No abnormalities were observed; (5) Han nationality; (6) Cognitive function assessment can be completed, and multimodal MRI data can be collected, once every 3 months for 3 consecutive times.
Exclusion criteria
Exclusion criteria: Exclusion conditions for subjects in the NC group: (1) There are contraindications in claustrophobia that cannot be examined by MRI, including metal dentures, etc .; (2) Left-handed or double-handed. aSAH exclusion conditions (1) Cognitive impairment caused by severe depression (2) Delirium acute encephalopathy syndrome; (3) Other diseases of the nervous system that can cause cognitive dysfunction (such as brain tumors, Parkinson's disease, encephalitis, Epilepsy, etc.); (4) The aSAH was caused by brain trauma; (5) Other systemic diseases that can cause cognitive damage, such as abnormal thyroid function, severe anemia, syphilis, HIV, etc .; (6) People with a history of mental illness or congenital Those who are stunted; (7) People with severe hearing and vision impairments who cannot cooperate with the examination; (8) Left-handed or double-handed people; (9) Cryophobia, which contains metal that cannot be examined by MRI, including metal denture Such as MRI contraindications, those who cannot complete MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total-Tau protein;phosphorylated tau on amino acid 181;amyloid beta 1-40;amyloid beta 1-42;Urine aSAH7c-NTP;functional MRI;neuropsychological test scale;event related potential; | — |
Secondary
| Measure | Time frame |
|---|---|
| aneurysm size;aneurysm site;Hunt-Hess grading; | — |
Countries
China
Contacts
Public ContactHongqi Zhang
Xuanwu Hospital, Capital Medical University
Outcome results
None listed