Malignant tumor
Conditions
Interventions
Case series:pd-1 inhibitor
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. male or female, aged 18 to 70 years; 2. locally advanced and metastatic malignant tumor confirmed by histological and/or cytological examinations; 3. Imaging diagnosis has at least one measurable lesion based on recist1.1; the expected survival time is longer than 12 weeks, and can be followed up; 4. fresh tumor tissue can be obtained; 5. physical condition: ECOG score is less than or equal to 2 points; 6. the results of blood routine, liver, kidney function and hemagglutination tests met the following criteria: neutrophil(> 1.5 *10^9/L), hemoglobin(> 90g/L), platelet(>100*10^9/L),aspartate aminotransferase (AST) normal upper limit), alanine aminotransferase (ALT) < 2.5 ULN, total bilirubin (TIBC) < 1.5 ULN, serum creatinine (CR) < 1.5 ULN; 7.patients voluntarily signed informed consent and had good compliance.
Exclusion criteria
Exclusion criteria: 1. BMI =10% within 2 months before screening; 2. history of gastrointestinal perforation or fistula or a high risk of bleeding within half a year before medication; 3. Previous allergies to monoclonal antibodies, use of other immunosuppressants within 2 weeks before medication, vaccination of anti-tumor vaccine, active autoimmune disease, history of autoimmune disease, history of immunodeficiency disease, history of interstitial pneumonia, etc.; 4. Other serious diseases that may affect follow-up and short-term survival.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| drug sensitivity; | — |
Countries
China
Contacts
Public ContactXianbao Zhan
Shanghai Changhai Hospital
Outcome results
None listed