Perioperative neurocognitive impairment
Conditions
Interventions
Case series:Nil
Sponsors
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Aged > 65 years; 2. Patients undergoing total knee or hip arthroplasty (elderly patients with joint replacement are prone to PND); 3. ASA was classified as grade I or II (reducing the interference of complications); 4. Have junior high school or above education level (can read various scales); 5. Clearly understand and volunteer to participate in the study, and sign the informed consent by the person or legal client.
Exclusion criteria
Exclusion criteria: 1. Acute heart failure; unstable angina pectoris; myocardial infarction within 6 months before screening; resting electrocardiogram heart rate 2.5 ULN), TBIL (> 1.5 ULN); 6. Renal dysfunction: urea or urea nitrogen (> 1.5 ULN), serum creatinine greater than the upper limit of normal value; 7. There were history of drug abuse, drug abuse and alcoholism in the two years before the screening period. Alcohol abuse was more than 2 units of alcohol per day (1 unit = 360 mL beer or 45 mL alcohol 40% white wine or 150 mL wine); 8. Patients who did not receive regular antihypertensive therapy or poor blood pressure control (seated systolic blood pressure (> 180 mmHg or 105 mmHg) during screening; 9. Benzodiazepines and/or anticholinergics were discontinuously administered daily for one month or nearly three months; 10. Anaphylaxis or contraindication to benzodiazepines, opioids, propofol, etc. 11. The researchers did not consider it appropriate for patients to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lncRNA;Incidence of PND; | — |
Countries
China
Contacts
Public ContactKeqiang He
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Outcome results
None listed