irreversible pulpitis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate the clinical trial and sign the informed consent form; Aged 18 to 70 years old; 2. Clinical examination reveals deep caries or secondary deep caries in the crown of the tooth; 3. No symptoms of the tooth, or had occasionally cold stimulation sensitivity, may had a history of spontaneous pain; 4. Cold test of the tooth shows normal, or the pain caused by the cold stimulation does not last more than 2 mins; 5. Percussion of the tooth shows normal or uncomfortable; 6. The tooth does not loosen; 7. X-ray and CBCT images show radiolucency near or reaching the pulp cavity in the crown. There was no radiolucency around the apical apex or slight enlargement exists in periapical membranes; 8. During the treatment procedure, the pulp does not expose until all decayed lesions are removed. The formed pulp tissue was observed under the microscope. The pulp was not completely liquefied and necrotic. The pulp bleeds after pulp exposure, after 5 mins, no active bleeding occurred.
Exclusion criteria
Exclusion criteria: 1. Serious systemic and organic diseases; 2. Cracks exist across the marginal ridge in crown, vertical root fracture or occlusal trauma existed; 3. Hot test shows severe pain; 4. Poor oral hygiene, the gum of the tooth is red and swollen, bleeding occurs after periodontal probing, the depth of periodontal pocket>4mm, combined periodontal-endodontic lesions exist; 5. Periapical lesion, internal or external root resorption can be observed in X-ray and CBCT images; 6. Patients had taken antibiotics within 4 weeks; 7. Patients who prepare to pregnant, during pregnancy, or being lactation; patients with systemic disease or have long-term medication history; 8. During the treatment, the edges of the tooth are located under the gingiva after the decayed lesions removed; when collecting the exudate of the pulp, cannot avoid the contamination of gingival crevicular fluid, saliva or gingival bleeding; 9. Cannot return to the hospital attend the follow-up on time; 10. The researchers believe that any situation that are not suitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| electric pulp test;periapical tissue;clinical exam; | — |
Countries
China
Contacts
Beijing Stomatological Hospital, Capital Medical University