irritable bowel syndrome
Conditions
Interventions
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Abdominal pain group (n=40): IBS-D patients who met the diagnostic criteria of Rome IV, without abdominal discomfort; Abdominal discomfort group (n=40): mainly abdominal discomfort, and in accordance with other conditions in the Rome IV diagnostic criteria, no abdominal pain, that is, recurrent episodes of abdominal discomfort associated with defecation. IBS-D Rome IV diagnostic criteria: recurrent abdominal pain, pre-diagnosis symptoms for at least 6 months, the average episode in the past 3 months at least 1 day per week, accompanied by the following 2 or more symptoms: (1) related to defecation; (2) the frequency of bowel movements increased at onset; (3) stool form became loose at onset [more than 25% of the stool form were loose (pasty) feces or watery feces (type 6 or 7 of the Bristol Stool Form Scale), and less than 25% of the stool form were dry (Type 1 or 2 of the Bristol Stool Form Scale). Patients with IBS-D who participated in the constant pressure device and rs-fMRI study were also required to meet the following conditions: (1) The frequency of abdominal pain/abdominal discomfort was at least 2 times/week, and typical symptoms occurred within 2 days; (2) The intensity of abdominal pain/abdominal discomfort is medium to severe (VAS = 4 points). 2. Healthy control group (n=20): 1. Healthy person matched with gender, age, height and body weight of IBS-D patients; 2. No history of digestive tract disease, no abdominal pain or abdominal discomfort, stool form between 3~5 type of the Bristol Stool Form Scale, frequency of defecation >=3 times/week~<=3 times/day; 3. Blood routine, urine routine, stool routine and occult blood, blood chemistry test are normal within 3 months, and colonoscopy is normal within 1 year.
Exclusion criteria
Exclusion criteria: 1. Those who have severe heart, liver, kidney and metabolic diseases; 2. Apply immunosuppressive agents or glucocorticoids within six months; 3. Abuse of alcohol, poison and/or drug history;Pregnancy, breastfeeding women; 4. Have a history of abdominal surgery (without complications such as appendectomy, caesarean section); 5. Severe psychiatric diseases, depressive episodes, obsessive-compulsive disorder; claustrophobia; 6. There are signs of alarm (such as fever, weight loss, blood in the stool or black stool, anemia, abdominal mass and other symptoms and signs that cannot be explained by functional diseases).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| expression of PGP 9.5;expression of SP;expression of TRPV1;expression of MC;visceral sensitivity;MRI sequence;scales; | — |
Countries
China
Contacts
Public ContactFang Xiucai
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed