colorectal cancer with liver metastasis
Conditions
Interventions
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Have a liver metastatic colorectal cancer diagnosed by cytology, histology, or radiology; 2. Have an Karnofsky performance status (PS) >=70; 3. Metastatic liver tumors are able to be radically ablated: single tumor with maximum diameter =1500/uL; Hemoglobin>=8 g/dL; Platelets>=80,000/uL; Creatinine=18 years of age, at the time of signing the informed consent; 8. The participant (or legally acceptable representative if applicable) provides written informed consent/assent for the study.
Exclusion criteria
Exclusion criteria: 1. Have contraindications for liver tumor ablation or unable to do radical ablation; 2. Need to combine with other local treatment for metastatic liver tumors, such as radiation; 3. Have central neural system disease and pia mater disease; 4. Have other serious disease, such as congestive heart-failure (Grade III or IV according to the New York heart association grading system); unstable angina; myocardial infarction within the last 6 months; serious arrhythmia; QT prolongation; HIV infection; mental disorders; drug abuse; 5. Have infection which needs intravenous antibiotic treatment; 6. A female participant who is pregnant or breastfeeding. Participants Reject contraception during the study; 7. Have second primary malignancy; 8. Allergic to CT or MRI contrast agents; 9. Participants of poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ctDNA; | — |
Secondary
| Measure | Time frame |
|---|---|
| tumor mutation burden; | — |
Countries
China
Contacts
Public ContactMeng Zhiqiang
Fudan University Shanghai Cancer Center
Outcome results
None listed