Cardiovascular reaction
Conditions
Interventions
Group A:Before induction,pump at 0.8 µg / kg dexmedetomidine + 20 mL NS(injection completed within 10 minutes).
Group B:Before induction,pump at 0.75 mg / kg esketamine + 20 mL NS(injection completed within 10 minutes).
Group C: 20 mL NS(injection completed within 10 minutes).
Sponsors
Sun Yat-Sen University Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. ASA I-II grade; 2. Aged 18-75 years; 3. Patients undergoing double-lumen tracheal intubation; 4. Preoperative examination without tracheal intubation.
Exclusion criteria
Exclusion criteria: 1) Patients with uncontrolled hypertension, severe arrhythmia, history of coronary heart disease, cerebral hemorrhage, cerebral infarction, or other cardiovascular and cerebrovascular diseases; 2) Patients with liver and kidney insufficiency, patients with chronic obstructive pulmonary disease; 3) The patient suffers from mental diseases; 4) Allergy to test drugs and other anesthetic-induced drugs; 5) Participants in other clinical trials in the study; 6) Patients who are expected to have difficulty intubation or need multiple attempts at intubation; 7) Women who are pregnant; 8) Those who have taken cardiovascular drugs before entering the house.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in heart rate and baseline heart rate at each time point, incidence and duration of stress response (maximum heart rate - baseline heart rate); | — |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular function;perioperative low blood pressure, high blood pressure, cardiac arrhythmia events (see annex), postoperative hospital stay, and other adverse events within 30 days after surgery;each period of blood pressure and ST segment changes; | — |
Countries
China
Contacts
Public ContactLin Wenqian
Sun Yat-Sen University Cancer Center
Outcome results
None listed