Centrally mediated abdominal pain syndrome
Conditions
Interventions
Group A:Pinaverium bromide 50mg p.o. t.i.d.
Group B:Pinaverium bromide 50mg p.o. t.i.d. and Pregabalin 75mg p.o. t.i.d.
Group C:Pregabalin 75mg p.o. t.i.d.
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age: 18 to 70 years old (male or female). 2. In accordance with the Roman ? functional gastrointestinal disease diagnostic criteria: about CAPS symptoms should be at least 6 months, and meet the following criteria for the diagnosis of nearly three months. Persistent or nearly persistent abdominal pain; Has nothing to do with physical behavior (eating, defecating, menstruation, etc.) or only occasionally; Abdominal pain caused by daily work, life restrictions; Pain is not a disguise; Abdominal pain cannot be explained by other organic, functional gastroenteropathy or other diseases. 3. Subjects understand the whole clinical study process, and have the ability to cooperate with the completion of the whole follow-up and efficacy evaluation.
Exclusion criteria
Exclusion criteria: 1. Have used pregabalin within 30 days or are allergic to pregabalin; 2. The use of narcotic drugs, non-narcotic analgesics, gastrointestinal antispasmodic drugs, proton pump inhibitors, sleeping pills; 3. Gastrointestinal ulcer, tumor, inflammation and other organic lesions found by gastroenteroscopy; 4. Have a history of mental illness or cognitive impairment; 5. Alcohol dependence; 6. Have serious heart, lung, liver, kidney and other chronic diseases; 7. Planned pregnancy or gestation, breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abdominal pain score; | — |
Countries
China
Contacts
Public ContactWei Han
Qilu Hospital of Shandong University
Outcome results
None listed