cancer pain
Conditions
Interventions
Group A :PCA intravenous infusion with hydromorphone
Group B:PCA intravenous infusion with morphine
Sponsors
Fuling Central Hospital of Chongqing City
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Subjects fully understand and voluntarily sign informed consent; (2) Aged 18 years or above, no gender restriction; (3) Cancer pain patients with NRS score >= 4, with an estimated survival time of more than 1 month; (4) Can objectively describe symptoms without severe infection or respiratory insufficiency; (5) No severe blood coagulation dysfunction; patients without severe liver and kidney dysfunction: generally no more than 2 times the upper limit of normal value. Patients with liver cancer (including metastatic liver cancer), bile duct cancer, and pancreatic cancer can be relaxed to 5 times the normal upper limit; (6) Patients without a history of drug abuse; (7) Non-pregnant and lactating women; subjects (including male subjects) who did not have a pregnancy plan within 1 month after the end of the trial; (8) did not participate in the drug test (including the test drug) within 3 months before the test.
Exclusion criteria
Exclusion criteria: (1) Radiotherapy should be performed within 4 weeks before the trial, and anti-tumor treatment such as chemotherapy or molecular targeted therapy should be performed during the trial; (2) sponsors or researchers directly participating in the trial or their family members; (3) Patients with respiratory depression but lack of CPR devices or monitoring facilities, or have shown cyanosis, increased intracranial pressure and craniocerebral injury; bronchial asthma; decompensated pulmonary heart disease; hypothyroidism; cortical function Incompleteness; benign prostatic hyperplasia, dysuria; severe hepatorenal dysfunction; shock before correction; presence or risk of progression to gastrointestinal obstruction, especially in patients with paralytic intestinal obstruction. (4) Those who are allergic to hydromorphone, hydromorphone salt, morphine and other ingredients in medicines; (5) The researcher believes that there is no reason to be selected; (6) People with brain metastases or mental symptoms; (7) Researchers judge that cancer pain can be solved by emergency surgery (such as intestinal obstruction, pathological fracture).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain assessment;Anxiety score;Depression score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disturbance of pain to daily life;Daily pain relief rate;Patient satisfaction with analgesic treatment;Patient compliance with analgesic treatment; | — |
Countries
China
Contacts
Public ContactZhou Qi
Department of Oncology, Fuling Central Hospital of Chongqing City
Outcome results
None listed