Cerebral artery stenosis
Conditions
Interventions
Experimental group:0.2g DL-3-n-butylphthalide
placebo group:0.02g DL-3-n-butylphthalide
Sponsors
Department of Neurology, Air Force General Hospital of the Chinese PLA (People's Liberation Army)
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Between 30 and 80 years old; 2. Primary school education or above; 3. MRA, CTA or DSA show that more than 75% stenosis exists in the carotid artery system; 4. The patients were asymptomatic, or without transient ischemic attack (TIA) and acute cerebral infarction within 2 week; 5. SPECT showed decreased cerebral blood flow (CBF) in the middle cerebral artery supply area; 6. According to the provisions of GCP, obtain informed consent and volunteer.
Exclusion criteria
Exclusion criteria: 1. Patients with stenosis of vertebral basilar artery system >=50% or more, or with embryonic brain; 2. MRI showed infarction in middle cerebral artery blood supply area >=15mm, or infarction in cortical area, or infarction in cerebellum area; 3. Patients who need carotid stents or carotid endarterectomy; 4. Patients who do not have access to mri or SPECT (such as allergies); 5. Pregnant or lactating women; 6. Examination confirmed the existence of brain tumors, traumatic brain injury, brain infection, degeneration, inheritance and other brain diseases; 7. With severe respiratory, digestive, tumor and other systemic diseases, the survival time is less than 6 months; 8. Abnormal liver and kidney function was examined in the laboratory, namely ALT or AST 1.5 ULN, or creatinine >=140 umol/L; 9. Mentally ill; 10. People who are allergic to butylphthalide; 11. Other conditions considered inappropriate by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral blood flow; | — |
Countries
China
Contacts
Public ContactShi Jin
Department of Neurology, Air Force General Hospital of the Chinese PLA (People's Liberation Army)
Outcome results
None listed