Acute lung injury with sepsis
Conditions
Interventions
Control group:Conventional treatment
Sponsors
Affiliated Hospital of Chengdu University of traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) The patient's aged 18-80 years; (2) The course of disease is within 12-48 hours, which meets the diagnostic criteria for sepsis and acute lung injury [28,29,30]; (3) Oxygenation index (PaO2 / FiO2) <=200 at ARDS; (4) Patients with mechanical ventilation; (5) The study complies with the Helsin Declaration and Chinese clinical trial research regulations. The patient or his family knows the research content and voluntarily signs the informed consent form.
Exclusion criteria
Exclusion criteria: (1) pregnant and lactating women; (2) Those who are allergic to the drugs used in the program; (3) Those with surgical indications; (4) Patients with other serious physical diseases, AIDS, and malignant tumors; (5) Patients who are expected to die or give up active rescue within 12 hours of entering the ICU and are unwilling to undergo conventional supportive treatment by Western medicine; (6) Patients with contraindications to femoral artery catheterization, patients with contraindication to central venous catheter placement, and patients with contraindications to blood transfusion (7) Patients with chronic heart failure or end-stage multiple organ failure; (8) currently participating in other drug researchers; (9) An employee of the research site or a family member of an employee of the research site.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality;Indicators of inflammatory response;Indicators of lung injury;Molecular biological marker lncRNA;Biochemical Indicators;Coagulation;No ventilator days;APACHEII score;SOFA score;LIS score;RASS score; | — |
Countries
China
Contacts
Public ContactPeiyang Gao
Department of Critical Medicine, Affiliated Hospital of Chengdu University of traditional Chinese Medicine
Outcome results
None listed