Alzheimer's disease, vascular dementia
Conditions
Interventions
Case series:Nil
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for AD: 1. Patients meet the diagnostic criteria of DSM-5 for major neurocognitive disorders and the diagnostic criteria of IWG-2 for AD, aged 50-85 years, and with an educational level of no less than 3 years; 2. Presence of an early and significant episodic memory impairment, gradual and progressive change in memory function reported by patient or informant over more than 6 months, objective evidence of anamnestic syndrome of the hippocampal type; CDR score = 1 to 2, MMSE score 10~26; 3. No evidence of significant cerebrovascular disease is shown on MRI, such as multiple cortical infarction or strategic infarction, lacune in basal ganglia area >1, and severe white matter hyperintensities (WMH); Fazekas score 3 months; absence of dementia; MMSE score > 24, CDR score = 0.5; 3. No evidence of significant cerebrovascular disease is shown on MRI, such as multiple cortical infarction or strategic infarction, lacune in basal ganglia area >1, and severe white matter hyperintensities (WMH); Fazekas score =3) supratentorial subcortical lacunes (3–15 mm in diameter), with/without WMH; (2) moderate to severe WMH according to the Fazekas rating scale >= 2 with/without lacunes; (3) one or more lacunar infarcts outside the brainstem, strategically placed in the subcortical deep grey matter. Inclusion criteria for healthy control: 1. Absence of subjective memory complaints, and performance within the normal range on neuropsychological measures; age range 50-85 years, with an educational level of no less than 3 years; 2. CDR score = 0, MMSE score > 26; 3. No clinically significant atrophy in the medial temporal lobe or other brain areas on MRI, no extensive WMH, Fazekas score < 2.
Exclusion criteria
Exclusion criteria: 1. Cognitive impairment caused by other central nervous system diseases, such as frontotemporal lobe degeneration, dementia with Lewy bodies, Parkinson's disease dementia, multiple sclerosis and hydrocephalus; 2. Cognitive impairment caused by other medical conditions, such as thyroid dysfunction, vitamin B12 deficiency, syphilis or HIV infection; 3. Medication for cogntive impairment or cerebrovascular disease is adjusted within 4 weeks before baseline; 4. A history of drug or alcohol abuse; 5. Severe visual or auditory disability that could influence performance on cognitive assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cerebral blood flow;brain volume;brain function;the integrity of white matter; | — |
Secondary
| Measure | Time frame |
|---|---|
| AVLT;BVMT-R;SDMT;TMT-A/B;BNT;COWAT;DS;SCWT;Verbal fluency test;MMSE;ADL;CDR;NPI;CDU;TCD; | — |
Countries
China
Contacts
Public ContactNan Zhang
Tianjin Medical University General Hospital
Outcome results
None listed