Mild Cognitive Impairment (MCI)
Conditions
Interventions
Probiotics group:clostridium caseinate enterococcus triad, 400mg, tid
control group:no probiotics supplement
Sponsors
Department of Geriatrics, the First Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. aged >=65 years, regardless of gender; 2. first MMSE cognitive score = 3 months, 3. overall cognitive function and general daily activity of living are normal. MMSE >= 20 (primary school) or >= 24 (junior high school or above), ADL<= 26, 4. excluding other causes of cognitive decline.
Exclusion criteria
Exclusion criteria: (1) disturbance of consciousness; (2) other neuropsychiatric diseases with effects on cognitive function (severe Parkinson's disease, epilepsy, schizophrenia); (3) patients with severe liver and kidney function impairment, asthma, hypothyroidism, VitB12, and folate deficiency, and intestinal obstruction; (4) no carers, unable to supervise regular drug use; (5) patients who were unable to complete the relevant scales by influencing cognitive function assessment before enrollment; (6) those who had been given probiotics for 4 weeks before entering the group and were allergic to milk and probiotics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA);Pittsburgh sleep quality index scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Evaluation (MMSE);Activities of Daily Living (ADL); | — |
Countries
China
Contacts
Public ContactWei Ge
The First Affiliated Hospital of Air Force Medical University
Outcome results
None listed