Knee osteoarthritis
Conditions
Interventions
Buprenorphine group:Buprenorphine transdermal patch 2.5mg applied to deltoid muscle 12h before surgery
Celecoxib group:Celecoxib 200mg orally 12h before surgery
Blank control group:No advanced analgesia
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: The patients undergoing first total knee arthroplasty performed by the same group of surgeons still had moderate to severe pain (NRS score of sports pain> 3) in the outpatient follow-up after discharge (1 month after surgery) and the patients gave informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of severe cardiopulmonary and cerebrovascular diseases, patients with abnormal liver and kidney function, patients with active peptic ulcer or gastrointestinal bleeding; 2. Patients allergic to opioids and sulfa drugs; 2. Patients with hip joint disease, lumbar spine disease, neurogenic pain and other comorbidities; 3. Have a long history of COX-2 inhibitors and opioids; 4. Patients with deep infection or deep vein thrombosis in the early postoperative period; 5. Patients who cannot cooperate with follow-up and rehabilitation guidance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain(Mean resting pain and movement pain);Knee flexion and extension;drug's adverse reactions; | — |
Countries
China
Contacts
Public ContactYin Xiaoli
Lanzhou University Second Hospital
Outcome results
None listed