Normal tension glaucoma
Conditions
Interventions
treatment group :IOP reduction (drug laser operation)
Natural cause group:Nil
Sponsors
Beijing Tongren Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) diagnosed as normal tension glaucoma; open angle with typical glaucoma optic disc change and retinal nerve fiber layer defect. Glaucomatous visual field damage for at least two consecutive times: at least three continuous scotoma (P < 5%, and at least one P < 1%) can be seen in the semi-lateral visual field. Fixation loss <=20% , false positive rate and false negative rate of visual field examination are required to be <=15%; Before enrolling, 24 h (Goldmann) intraocular pressure monitoring was performed 4 weeks after the cessation of the antihypertensive drugs. 24-hour intraocular pressure in both eyes was <=21mmHg; (2) signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) eye trauma or ophthalmic diseases that affect visual field, such as corneal lesions, cataracts, congenital optic disc abnormalities (such as optic nerve dysplasia above may cause visual field changes similar to glaucoma), retinal arteriovenous occlusion, diabetic retinopathy, retinal detachment, anterior ischemic optic neuropathy, etc.; (2) extremely high myopia (eye axis >=30mm or spherical mirror < -10.00ds), or myopic macular lesions such as choroid retinal fog-like atrophy, paint crack, choroid neovascularization, etc.; (3) the best corrected visual acuity < 0.6, thereby reducing the effect of refractive media opacity, such as cataracts (if cataract surgery was performed before baseline, it was not excluded; if cataracts worsened during the observation period, it was excluded); (4) the mean defect (MD) of the first visual field examination was less than -20.0db, and it was difficult to judge the progress of the severe initial visual field defect; (5) secondary glaucoma; (6) local eye anti-glaucoma surgery, vitrectomy may affect the results of intraocular pressure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IOP;visual field; | — |
Countries
China
Contacts
Public ContactNingli Wang
Beijing Tongren Hospital Affiliated to Capital Medical University
Outcome results
None listed