Cryptococcal meningitis
Conditions
Interventions
Conventional VPS group:Antifungal Induction Therapy + VPS after Induction Therapy
Early VPS Group:Early VPS surgery + Postoperative antifungal therapy
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Diagnostic criteria: patients who meet the US IDAS 2010 cryptococcosis treatment guidelines and the cryptococcal microbiological identification indicators within the consensus of 2018 Chinese cryptococcal meningitis experts; 2. The patient has a clear intracranial pressure (more than 200mmH2O or 15mmHg) in the lumbar puncture; or the patient has clinical manifestations of intracranial hypertension such as headache, nausea and vomiting and papilledema; 3. Aged 16 and 65 years; 4. All patients signed a written informed consent to participate in the clinical study.
Exclusion criteria
Exclusion criteria: 1. diagnosis of patients with human immunodeficiency virus (HIV) infection; 2. patients who have been treated with immunosuppressive drugs for a long time after organ transplantation; 3. Those with poor general condition, unable to cooperate with the relevant assessment process, and need to take rescue treatment measures; 4. patients with bacterial central nervous system infections; 5. Patients who are unwilling to participate in clinical trials or inaccessibility.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optic nerve function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cryptococcus meningitis cure rate;Median cure time;Average treatment cost;Mental state (anxiety) improvement rate;Mental state (depression) improvement rate; | — |
Countries
China
Contacts
Public ContactFeng Qin
Department of Neurosurgery, The Third Affiliated Hospital of Sun Yat-sen University-Lingnan Hospital
Outcome results
None listed