Acute coronary syndrome
Conditions
Interventions
Acute coronary syndrome group:Percutaneous coronary intervention
Acute coronary syndrome with renal insufficiency group:Percutaneous coronary intervention
Renal insufficiency:none
Healthy control group:none
Sponsors
Hao Zhou
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All the enrolled patients were divided into 4 groups of acute coronary syndrome (acs). Renal insufficiency group was patients with chronic renal insufficiency without acute coronary syndrome. Patients with acute coronary syndrome combined with renal insufficiency were patients with both acute coronary syndrome and chronic renal insufficiency. At the same time, healthy volunteers matched with age and sex were selected as the control group. Inclusion criteria: 1. Definition of acute coronary syndrome: it refers to the acute ischemic syndrome of the heart caused by the rupture of atherosclerotic plaque or fresh thrombosis secondary to erosion in the coronary arteries, including st-segment elevation myocardial infarction, non-st-segment elevation myocardial infarction and unstable angina pectoris. 1.1 diagnostic criteria for st-segment elevation myocardial infarction: elevation of troponin over 99% of the reference upper limit or elevation of creatine kinase isoenzyme over 99% of the reference upper limit. Electrocardiogram showed elevation of st-segment dorsal arch with one or more of the following conditions: persistent ischemic chest pain; Echocardiography showed abnormal segmental ventricular wall activity. Abnormal coronary angiography. 1.2 diagnostic criteria for non-st-elevation myocardial infarction: elevation of troponin over 99% of the reference upper limit or creatine kinase isoenzyme over 99% of the reference upper limit, accompanied by one or more of the following: persistent ischemic chest pain; The ecg showed new ST segment depression or T wave horizon and inversion. Echocardiography showed abnormal segmental ventricular wall activity. Abnormal coronary angiography 1.3 diagnostic criteria for unstable angina: negative troponin, ischemic chest pain, ecg manifestations of transient ST segment depression or t-wave diping and inversion, and rare ST segment elevation (spasmodic angina). 2. Definition of chronic renal insufficiency: the history of renal damage and injury was more than 3 months, and the glomerular filtration rate was <60ml/min·1.73m2.
Exclusion criteria
Exclusion criteria: 1) no abnormality was found in the results of coronary angiography; 2) liver dysfunction, transaminase was 3 times higher than the upper limit; 3) other iodine containing contrast agents should be injected into arteries or veins from 7 days before the operation to 72 hours after the operation; 4) during the experiment, metformin, aminoglycoside, diamicin B, chemotherapy drugs, non-steroidal anti-inflammatory drugs and other drugs for renal damage were applied; 5) patients with hypersensitivity to contrast agents; 6) preoperative patients with severe HYHA IV, myocardial infarction killip iii-iv, cardiogenic shock, malignant arrhythmia, etc., who need rescue; 7) thyroid dysfunction; 8) acute cerebrovascular disease; 9) patients with malignant tumor; 10) patients with intraoperative complications; 11) involving intestinal diseases; 12) had taken probiotics and antibiotics within one month before the test; 13) the patient did not agree to be included in the study; 14) any researcher who believes that the patient's condition will interfere with the clinical situation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 16srRNA;LC-MS/MS;Coronary angiography;Intracoronary ultrasound;B ultrasound of femoral artery;Carotid ultrasound;D dimer;thromboelasmogram;Collagen type I;Collagen type III;Transforming growth factor-Transforming growth factor-ß;matrix Metalloproteinases;ultrasonic cardiogram;Cardiac magnetic resonance;B ultrasound of renal artery; | — |
Countries
China
Contacts
Public ContactHao zhou
The First Hospital Affiliated of Wenzhou Medical University
Outcome results
None listed