Chronic obstructive pulmonary disease and pulmonary embolism
Conditions
Interventions
AECOPD with pulmonary embolism group:N/A
AECOPD without pulmonary embolism group:N/A
COPD stable period group:N/A
Healthy controll group:N/A
Sponsors
The First Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: COPD enrollment criteria: All patients with chronic obstructive pulmonary disease were diagnosed in accordance with the 2018GOLD Global Advocacy for Chronic Obstructive Pulmonary Disease. The stable period is at least 3 months, the respiratory symptoms are not aggravated, there is no adjustment treatment plan, the standard of acute exacerbation is short-term cough, cough, shortness of breath or wheezing, increased sputum or trait changes, need to adjust the treatment plan. Therefore, the diagnosis of pulmonary embolism is consistent with the "Guidelines for the Diagnosis of Pulmonary Thromboembolism in 2018", in which the direct sign of CTPA standard 1 is a low-density filling defect in the pulmonary artery, partially or completely enclosing the "orbital sign" within the opaque blood flow, or The lesion is completely filled and the distal vessel is not developed; 2 the indirect signs include the high-density zone of the wedge-shaped strip in the lung field or discoid atelectasis, the central pulmonary artery dilatation and the reduction or disappearance of the distal vessel distribution.
Exclusion criteria
Exclusion criteria: 1. There is contrast agent allergy, chronic kidney disease; 2. Massive pleural effusion; 3. Sepsis, ARDS patients; 4. Heart, liver and kidney and other important organ failure; 5. Primary venous thrombosis risk factors or trauma / Secondary thrombosis caused by long-term causes such as fracture, postoperative surgery, malignant tumor, acute myocardial infarction, stroke, congestive heart failure, oral contraceptives, etc.; 6. Patients with autoimmune diseases; 7. Mental disorders or unwillingness to participate in this Subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MCP-1;PTX-3;HMGB1; | — |
Countries
China
Contacts
Public ContactDeng Chaosheng
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Fujian Medical University
Outcome results
None listed