Multiple myeloma
Conditions
Interventions
2:long term VRD
2:short term VrD
Sponsors
the First Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of newly diagnosed MM patients by IMW diagnostic criteria; 2. Aged 50-80 years old; 3. ECOG score 0-2; Liver and kidney function: blood bilirubin =30ml/min, calculation formula: Male: creatinine clearance = [(140-age)x body weight (kg)]/[0.818 x serum creatinine concentration (umol/L)], or creatinine clearance = [(140 - age) x body weight (kg)] /[72 x serum creatinine concentration (mg / dl)]; women calculated according to the above formula x 0.85; 4. normal heart function: EF>50%; 5. Expected survival >=3 months; 6. Obtain informed consent signed by the patient or family member.
Exclusion criteria
Exclusion criteria: 1. There are other history of malignant tumors in the past 5 years; 2. HIV-positive, active tuberculosis, clinically active patients with hepatitis A, B, and C; 3. Other serious diseases that may limit the patient's participation in this trial (eg, advanced infection, uncontrolled diabetes, severe cardiac insufficiency or angina); 4. Systemic conditions are not suitable for chemotherapy; 5. pregnant or lactating women; 6. Combine other serious organic diseases and mental disorders; 7. Can't understand or follow the research plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete remission;ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;MRD;safety; | — |
Countries
China
Contacts
Public ContactHaitao Meng
the First Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed