Acute ischemic stroke
Conditions
Interventions
Control:SBP 140-180 mmHg
Intensive BP lowering:SBP < 120 mmHg
Sponsors
The George Institute for Global Health (Australia) Beijing Representative Office
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years; 2. Diagnosis of AIS with LVO confirmed by brain imaging; 3. Fulfill local criteria for conduct of MT therapy; 4. Achieve successful recanalization (TICI score >=2b) after MT; 5. Provide written informed consent (or approved surrogate); 6. Persistent (2 readings =140 mmHg <3 hours after recanalization.
Exclusion criteria
Exclusion criteria: 1. Unlikely to potentially benefit from therapy (e.g. advanced dementia) or very high likelihood of death within 24 hours post-MT, judged by responsible treating clinician; 2. Other medical illness that interferes with outcome assessments and follow-up (e.g. known significant pre-stroke disability (mRS scores 3-5), advance cancer and renal failure); 3. Definite indication/contraindication to different intensities of BP lowering treatment; 4. Specific contraindications to any of the BP agents to be used (eg, patients who are hypersensitive (allergic) to any of the ingredients); 5. Patients with aortic isthmus stenosis and arteriovenous shunt (exception: patients with haemodynamically inactive dialysis shunt); 6. Lactating woman; 7. Currently participating in another trial which would interfere with outcome assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a shift analysis of mRS scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| sICH;Death and disability (mRS 3-6);Death;Disability (mRS 3-5);EQ-5D; | — |
Countries
China
Contacts
Public ContactCraig Anderson
The George Institute for Global Health (Australia) Beijing Representative Office
Outcome results
None listed