Acute carbon monoxide poisoning / carbon monoxide poisoning delayed encephalopathy
Conditions
Interventions
Experimental group:Treatment of delayed encephalopathy after acute carbon monoxide poisoning / carbon monoxide poisoning with butylphthalide
Control group:Conventional treatment
Sponsors
Baotou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Outpatient or ward patients will voluntarily participate in the trial and sign the informed consent by themselves or their legal representatives; 2. Medium and severe diagnostic criteria in Diagnostic Criteria for Occupational Acute Carbon Monoxide Poisoning formulated by the Ministry of Health were met; 3. Aged 18 to 80 years; 4. The course of disease was less than 48 hours from onset to admission; 5. Glasgow Coma Scale 3 to 12 points.
Exclusion criteria
Exclusion criteria: 1. Acute cerebrovascular disease and encephalopathy caused by other causes; 2. Mixed poisoning patients; 3. Past dementia or mental disorders; 4. Burns or injuries; 5. Severe diseases of heart, lung, liver, kidney, blood system and hematopoietic system; 6. Gastrointestinal diseases or gastrointestinal surgery may affect gastrointestinal absorption. 7. Serious infection uncontrolled; 8. Breast-feeding or pregnancy; 9. Anyone who has allergic history to celery or Enbipu in the past; 10. Patients with malignant tumors or undergoing antineoplastic therapy; 11. Butylphthalide was taken within 3 months prior to the date of informed consent; 12. Researchers think that it is not suitable for patients to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini Mental State Examination(MMSE); | — |
Secondary
| Measure | Time frame |
|---|---|
| daily living ability scale (BI score);European Five-Dimensional Health Scale (EQ-5D); | — |
Countries
China
Contacts
Public Contactzhang Jingfen
Baotou Central Hospital
Outcome results
None listed