Diminished ovarian reserve (DOR)
Conditions
Interventions
Group 1:Conventional incubators
Group 2:Time-lapse imaging system
Sponsors
Shanghai First Maternity and Infant Hospital Tongji University School of Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Infertile couples scheduled for their first or second IVF/ICSI cycle; 2. In line with DOR criteria (AFC<7 follicles or AMH<1.2ng/ml).
Exclusion criteria
Exclusion criteria: 1. Couples undergoing PGD and PGS; 2. Woman older than 45 years; 3. Women with congenital or secondary uterine abnormalities, such as uterine malformations including single-horned uterus, septate uterus or double uterus, adenomyosis, uterine submucosal fibroids, intrauterine adhesions; 4. Women with hydrosalpinx; 5. Women with recurrent miscarriage; 6. Women with polycystic ovarian syndrome (PCOS); 7. Women with endocrine or metabolic abnormalities (pituitary, adrenal, pancreas, liver or kidney).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative live birth of the trial IVF/ICSI cycle within 12 months of randomization; | — |
Secondary
| Measure | Time frame |
|---|---|
| Available embryo;Good quality embryo;Biochemical pregnancy;Clinical pregnancy;Multiple pregnancy;Ongoing pregnancy;Ovarian hyperstimulation syndrome (OHSS);Miscarriage;Ectopic pregnancy;Gestational diabetes mellitus (GDM);Hypertensive disorders of pregnancy;Antepartum haemorrhage;Preterm birth;Birth weight;Large for gestational age;Small for gestational age;Congenital anomaly;Perinatal mortality; | — |
Countries
China
Contacts
Public ContactMiaoxin Chen
Shanghai First Maternity and Infant Hospital Tongji University School of Medicine
Outcome results
None listed