Effect of Mei Mini Maze procedure combined with left T3-T4 sympathetic ganglion ablation on the efficacy of atrial fibrillation

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900027731

Enrollment

Unknown

Registered

2019-11-24

Start date

2020-01-01

Completion date

Unknown

Last updated

2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atrial fibrillation

Interventions

Experimental group:left T3-T4 sympathetic ganglion ablation plus Mei Mini Maze procedure

control group:left T3-T4 sympathetic ganglion ablation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. There is a history of paroxysmal/persistent atrial fibrillation (the evidence includes any of the following: Holter or 12-lead ECG recorded to atrial fibrillation), one or more medications are ineffective or unwilling to be treated with long-term medication; 2. Provide informed consent to participate in the study, follow-up trials and assessment procedures; 3. Patient aged 18-80 years old.

Exclusion criteria

Exclusion criteria: 1. Combined with coronary heart disease, valvular disease or congenital heart disease requiring surgical treatment 2. There are acute lesions, such as acute phase after myocardial infarction (within 3 months), acute heart attack or 3 months after new cerebral infarction; 3. a list of patients on heart transplant; 4. Life expectancy is less than 1 year; 5. There are other bleeding diseases that cannot be treated with anticoagulation; 6. left atrial thrombus; 7. the diameter of the left atrium is greater than 70 mm; 8. left ventricular ejection fraction is less than 30%; 9. cancer uncontrolled patients; 10. obvious liver and kidney function damage (and / or ALT, AST is 1 times higher than the upper limit of normal, CCr <50%); 11. History of previous cardiac surgery; 12. Women who are pregnant, breast-feeding, who are planning to become pregnant, or women of childbearing age who do not adopt reliable methods of contraception.

Design outcomes

Primary

Measure	Time frame
maintain sinus ratio;	—

Secondary

Measure	Time frame
blood pressure;blood pressure;heart rate;stroke;Systemic embolism;Rehospitalization rate;Hospitalization rate due to heart failure;Cardiovascular death;Sympathetic activity test;	—

Countries

China

Contacts

Public ContactJu Mei

Department of Cardiothoracic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University

ju_mei63@126.com+86 13801669185

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026