major depressive disorder
Conditions
Interventions
Experimental group:Hybrid-ECT
Sponsors
Second People's Hospital of Huizhou
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Male or female patient aged 18 to 60 years; 2. Patient met the following ICD-10 criteria and had an ECT indicationdepression (F32.2 major depressive episodes without psychotic symptoms; F32.3 major depressive episodes with psychotic symptoms); 3. Patient had an HAMD-24 score 21; 4. Patient was competent to provide informed consent; 5. Patient was sufficiently fluent in Chinese to ensure valid responses to the europsychological tests.
Exclusion criteria
Exclusion criteria: 1. Failure to respond to earlier ECT; 2. ECT or rTMS within the last 6 months; 3. Major depressive episodes of bipolar disorder with/without psychotic symptoms (ICD 31.4;F31.5); 4. Medication use incompatible with ECT treatment (such as lithium, benzodiazepine, antiepileptic; drugs, etc.). Use of these drugs will be stopped at least 5 half-lives before the start of treatment; 5. Inability to follow the study protocol; 6. Unstable, serious comorbid medical condition (Parkinsons disease, multiple sclerosis, stroke, alcohol use disorder, etc.) or history of epilepsy; 7. 20.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-24 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| PANSS;cognitive function;social function; | — |
Countries
China
Contacts
Public ContactBo-jian Tan
Second People's Hospital of Huizhou
Outcome results
None listed