PIS
Conditions
Interventions
Case series:tirofiban
Sponsors
The People's Hospital Liaoning Province
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Aged >=18 years old; (2) patients with progressive stroke diagnosed by head MRI or CT examination, within 72 hours of onset, in line with the 2018 guidelines for diagnosis and treatment of acute ischemic stroke in China, and with progressive exacerbation within 1 week of course of disease; (3) no significant sequelae after the first stroke or previous stroke (mRS=0-1); (4) agree to participate in this study, and give informed consent to the collection and preservation of case data and the follow-up process.
Exclusion criteria
Exclusion criteria: (1) CT examination found high-density lesions (hemorrhage), obvious mass effect with midline shift (large infarct range), 1/3 of the blood supply range of acute low-density lesions or disappeared cerebral fossa >MCA, intracranial tumors, arteriovenous malformations or subarachnoid hemorrhage; (2) coma or clinical evaluation (such as NIHSS>25) and/or other appropriate imaging confirmation of severe stroke; (3) accompanied by seizures; (4) a history of stroke within 3 months; (5) heparin was applied within 48h of onset, and aPPT exceeded the upper limit of normal value in the laboratory; (6) platelet count 180mmHg or DBP>110mmHg measured at intervals of at least 10 minutes and repeated three times; (8) blood glucose 400mg/dl(22.2mmol/l); (9) having a significant hemorrhagic disease within the current or previous 6 months; (10) in patients with oral anticoagulant drugs (such as warfarin), pt-inr >1.5; (11) a known history of intracranial hemorrhage or suspected intracranial hemorrhage (including subarachnoid hemorrhage); (12) during pregnancy or lactation; (13) a history of severe central nervous system damage (such as tumors, aneurysms, intracranial lesions, or age of surgery); (14) hemorrhagic retinal diseases, such as diabetes mellitus (visual impairment may indicate retinal hemorrhage) or other hemorrhagic eye lesions; (15) bacterial endocarditis, pericarditis and acute pancreatitis; (16) confirmed ulcerative gastrointestinal disease (within 3 months); (17) tumors with increased risk of bleeding; (18) severe liver diseases, including liver failure, cirrhosis, portal hypertension (esophageal varices), and active hepatitis; (19) a history of major surgery or severe trauma or craniocerebral trauma in the past 10 days; (20) disagree to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NIHSS score; | — |
Countries
China
Contacts
Public ContactChen Xin
The People's Hospital Liaoning Province
Outcome results
None listed