sepsis and septic shock
Conditions
Interventions
Conventional treatment group:Develop treatment plans based on guidelines and clinical experience
HAT group:5% glucose injection or saline injection 100ml + vitamin C injection 3.0g, intravenous infusion for more than 2 hours, every 12 hours
injection with hydrocortisone sodium succinate 100mg intravenously, every 12 hours
vitamin B1 injection 200mg intramuscular injection, once every 12 hours
Eslorol + HAT group:On the basis of HAT treatment, esmolol hydrochloride injection was pumped through deep intravenous micro pump
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who met all inclusion criteria were enrolled in the study: 1. aged >= 18 years; 2. met the diagnostic criteria for sepsis-3.0 sepsis prescribed by the American Society of Critical Care Medicine (SCCM)/European Critical Care Medicine (ESICM): a. Or confirmed infection: clinician diagnosis; b. Evidence of acute organ dysfunction: for patients with no chronic organ dysfunction (assuming a baseline SOFA score of 0): SOFA >= 2 points for patients with chronic organ dysfunction (SOFA score should be based on baseline conditions), SOFA elevation >= 2 points; 3. heart rate greater than 90 beats / min; 4. must undergo adequate fluid recovery.
Exclusion criteria
Exclusion criteria: 1. 3 months before sepsis systemic corticosteroid treatment, long-term use of beta blockers; 2. large doses of steroids; 3. immunosuppression; 4. pregnancy or lactation; 5. known glucose-6-phosphate dehydrogenase ( G-6PD) deficiency, known blood disease, bronchial asthma, sinus bradycardia, two to three degree atrioventricular block, severe chronic obstructive pulmonary disease, significant cardiac insufficiency (EF < 40%), severe valve Sexual heart disease (cardiac shock in contraindications to esmolol, some patients with septic shock may be excluded with cardiogenic shock); 6. known esmolol hydrochloride injection, vitamin C injection Liquid, injection of hydrocortisone sodium succinate, thiamine allergy; 7. patient's family refused.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial blood gas analysis;Blood routine test;Liver and kidney function test;Coagulation test;C-reactive protein test;Blood bacterial culture test;procalcitonin;Heparin binding protein; | — |
Countries
China
Contacts
Public ContactSun Tongwen
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed