central nervous system infectious disease
Conditions
Interventions
Gold Standard:The diagnostic criteria of encephalitis and meningitis are as described in the inclusion criteria.
Index test:nanopore 
Sponsors
Henan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 90 Years
Inclusion criteria
Inclusion criteria: Case definitions for encephalitis: Major criteria (required) Patients presenting to medical attention with altered mental status (decreased or altered level of consciousness or personality change) lasting >=24 hrs with no alternative cause identified, and/or generalized or partial seizures not fully attributable to a pre-existing seizure disorder or a simple febrile seizure. Minor criteria (>=2 points) Documented fever >=38 degree C within the 72 hrs before or after presentation New onset of focal neurologic findings CSF WBC count >=5/cubic mm Abnormality of brain parenchyma on neuroimaging suggestive of encephalitis that is either new from prior studies or appears acute in onset Abnormality on EEG that is consistent with encephalitis and not attributable to another cause; Case definitions for meningitis Patients presenting to medical attention with at least two of the four symptoms of headache, fever (documented fever >=38 degree C within the 72 hrs before or after presentation), neck stiffness, decreased level of consciousness (defined by a Glasgow Coma Scale score below 14) CSF white blood cell count >= 5/cubic mm.
Exclusion criteria
Exclusion criteria: Exclusion criteria for encephalitis: <=28 days of age; Non-infectious encephalitis, such as autoimmune disorders, paraneoplastic syndromes, NMOSD, neuropsychiatric involvement of rheumatic diseases HIV or syphilis infection History of recent (within 4 weeks before the onset of disease) vaccination Meningitis without clinical brain parenchyma involvement Absolute contraindications for lumbar puncture; Traumatic LP with obvious blood-contaminated CSF Pregnancy Refusal to sign the informed consent. Exclusion criteria for meningitis: <=28 days of age; HIV or syphilis infection Meningeal malignancy confirmed by CSF cytology Traumatic LP with obvious blood-contaminated CSF Pregnancy Refusal to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity,specificity,mistake diagnostic rate,pmission diagnostic rate,positive predictive value,negative predictive value,accuracy,Youden index,odd product,positive likelihood ratio,negative likelyhood ratio; | — |
Countries
China
Contacts
Public ContactWei Li
People's Hospital of Zhengzhou University, He'nan Provincial People's Hospital
Outcome results
None listed