Clinical study on the relationship between periodontal disease and rheumatic immune disease

Expression of cytokines and vitamin D in gingival crevicular fluid and peripheral blood of patients with periodontal disease and rheumatic immune disease

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900027619

Enrollment

Unknown

Registered

2019-11-21

Start date

2019-11-25

Completion date

Unknown

Last updated

2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Disease and Rheumatic Immune Disease

Interventions

Case group:None

Healthy control:None

Eligibility

Sex/Gender

All

Age

20 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Periodontitis patients with stage I ~III and grade A or grade B periodontitis meet the diagnostic criteria of periodontitis formulated by the American association of periodontitis (AAP) and European association of periodontitis (EFP) in 2017; Adjacent face CAL detected in =2 non-adjacent teeth, or CAL=3mm in buccal or lingual teeth, and periodontal pocket =3mm; 2. The inclusion criteria for patients with rheumatic immune diseases were that they were diagnosed as rheumatic immune diseases by rheumatologists and had healthy periodontal health; 3. Patients with rheumatoid immune disease + periodontitis: in line with the inclusion criteria of rheumatoid arthritis and periodontitis.

Exclusion criteria

Exclusion criteria: 1. Those who have no occlusion or cannot complete data collection; 2. Accompanied by systemic diseases, such as cardiovascular diseases, endocrine diseases, liver and kidney function damage and other autoimmune diseases; 3. A pregnant or lactating woman; 4. Smoking history; 5. Periodontal treatment history within half a year; 6. Those who have taken antibiotics within three months; 7. Took vitamin D preparations or hormones within three months.

Design outcomes

Primary

Measure	Time frame
25-(OH)D;interleukin-33;interleukin-10;interleukin-6;	—

Countries

China

Contacts

Public ContactLin Xiaoping

Shengjing Hospital Affiliated to China Medical University

xiaoping_ba@126.com+86 18940251456

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026