Effect of quadratus lumborum block on cognitive function and HMGB1 after abdominal surgery in elderly patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900027574

Enrollment

Unknown

Registered

2019-11-19

Start date

2020-01-01

Completion date

Unknown

Last updated

2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

perioperative neurocognitive dysfunction

Interventions

experimental group:quadratus lumborum block

control group:no invtervention

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Aged >= 65 years; American society of anesthesiologists (ASA) classification I ~ II; Laparoscopic radical gastrectomy under general anesthesia; Primary school education or above; Preoperative MMSE score >=24 points.

Exclusion criteria

Exclusion criteria: Severe visual and auditory disorders; Unable to cooperate with the completion of the test; Serious heart, lung, brain, liver and kidney diseases; Preoperative mental illness and cognitive impairment; A history of drug abuse or addiction; Local anesthetic allergy history; Puncture site infection.

Design outcomes

Primary

Measure	Time frame
PND;	—

Secondary

Measure	Time frame
MAP;HR;propofol dosage;remifentanil dosage;VAS;sufentanil dosage 24h after surgery;HMGB1;TNF-a;IL-6;IL-1ß;	—

Countries

China

Contacts

Public ContactZhu Manhua

Ningbo Medical Center Lihuili Eastern Hospital

jszhumanhua@163.com+86 18868658089

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 23, 2026