Multiple myeloma
Conditions
Interventions
Case series:Refractory/relapsed multiple myeloma patient group
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnosis of active multiple myeloma patients, refractory recurrence; 2. Secretory multiple myeloma with measurable indicators; 3. Age 18 or older, gender is not limited; 4. The general condition of the body is scored ECOG0-2, and the expected survival period is more than 3 months; 5. Serum liver enzyme value =0.5x10^9/L, platelet count >=70x 10^9/L, glomerular filtration rate (eGFR) >=50 mL/min; 6. Left ventricular ejection fraction is normal, no obvious heart, lung and other dysfunction (<=1 degree); 7. Can accept adverse reactions and therapeutic effects according to the test requirements; 8. Patients must have the ability to understand and voluntarily sign an informed consent form, and the informed consent form must be signed prior to any testing process.
Exclusion criteria
Exclusion criteria: 1. Initially diagnosed multiple myeloma patients; 2. There are more than grade 3 peripheral neuropathy when enrolled; 3. Those who are receiving other effective treatments; 4. Patients with severe lung and heart dysfunction (including history of prolonged QTc interval, ventricular tachycardia, ventricular fibrillation, myocardial infarction) or other serious medical problems; 5. Pregnant and lactating patients; 6. Allergies, such as those who have a history of allergies to two or more drugs or foods; or those who are known to be allergic to the components of the drug; 7. People with mental disorders that are difficult to control; 8. People with active infections; 9. Patients who had previous grade 4 thrombocytopenia (PLT <=25x10^9/L) with bortezomib.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood routine;Biochemistry;Electrocardiogram; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proteasome activity;Cardiac ultrasound (angiography);M protein of blood;M protein of urine; | — |
Countries
China
Contacts
Public ContactJin Lu
Peking University People's Hospital
Outcome results
None listed