Acute ischemic stroke
Conditions
Interventions
Group 1:1.Basic treatment: According to the patient's clinical history, symptoms and other specific conditions, the patient-in-charge physician refers to "China's Guidelines for the Diagnosis and Trea
Group 2:Patients who did not use anisoprofen hydrobromide injection
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with ischemic stroke admitted to hospital (meet with the "China Acute Ischemic Stroke Diagnosis and Treatment Guide 2014" ischemic stroke diagnostic criteria), CT/MRI examination to exclude cerebral hemorrhage; (2) Aged >= 18 years, gender is not limited; (3) The time from onset to admission is <= 30 days; (4) The patient or family member informed the study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Neuroimaging (CT/MRI) confirmed acute intracranial hemorrhage, tumor, encephalitis or other non-vascular intracranial lesions; (2) Pregnant and lactating women; (3) Poor compliance, unable to complete or refuse to complete the follow-up; (4) Those with severe organ dysfunction; (5) The condition is critical and the life expectancy is less than three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with 90-day adverse prognosis (i.e. death or disability, modified Rankin scale, mRS = 3-6 points); | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of NIHSS score at discharge compared with baseline and comparison between the two groups;Incidence of hemorrhagic transformation after cerebral infarction during hospitalization;90-day mortality rate;90-day mRS grade migration;90-day recurrence of stroke;Improvement of cerebral collateral circulation/perfusion during CTA and/or CTP examinations 7-14 days after the start of medication;The change of brain edema in patients with CT/MRI examination 7-14 days after the beginning of medication;Cardiovascular adverse events (heart rate, blood pressure) during medication;Adverse events during medication: facial flushing, gastrointestinal reaction, blurred vision, pulmonary infection, dysuria, urinary retention, headache;Vital signs (temperature, pulse, breathing, blood pressure) during medication;ECG examination during medication;Laboratory examination during medication (blood routine, blood sugar, blood lipid, liver and kidney function, myocardial enzymes, blood electrolyte, coagulation function); | — |
Countries
China
Contacts
Public ContactWu Bo
West China Hospital of Sichuan University
Outcome results
None listed