Schizophrenia
Conditions
Interventions
Group A:Patients treated with risperidone alone for 8 weeks
Group B:Patients treated with risperidone and 5 mg/day aripiprazole for 8 weeks
Group C:Patients treated with risperidone and 10 mg/day aripiprazole for 8 weeks
Sponsors
Shandong Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) 18-45 years of age; (2) Diagnosed with schizophrenia; (3) Positive and Negative Rating Scale (PANSS) total score>=60; (4) First episode or no any treatment was used within 3 months.
Exclusion criteria
Exclusion criteria: (1) With other psychotic disorder; (2) Other serious physical illness including severe cardiovascular, hepatic, or renal disease and so on; (3) Diagnosed with pituitary tumor, hypothalamic disease, thyroid disease, primary or secondary amenorrhea; (4) Elevated serum prolactin levels at baseline (>24ng/ml in female and >20ng/ml in male); (5) Taking medicine which can influence prolactin levels like estrogen; (6) Current substance abuse (including alcohol consumption).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum prolactin levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Positive and Negative Syndrome Scale (PANSS);CGI; | — |
Countries
China
Contacts
Public ContactGuanglei XUN
Shandong Mental Health Center
Outcome results
None listed