osteoarthritis
Conditions
Interventions
Group A:Tranexamic acid (iv)
Group B:Tranexamic acid + dexamethasone
Group C:dexamethasone
Sponsors
Department of Orthopedics, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) patients diagnosed as osteoarthritis of the knee with unilateral initial artificial THA indication;All patients had no previous history of knee surgery, and all patients signed the operation and anesthesia protocol and the informed consent to be included in the study. (2) above the age of 18 years.
Exclusion criteria
Exclusion criteria: (1) history of thromboembolic disease (i.e., deep vein thrombosis (DVT), or pulmonary embolism (PE)), thrombotic disease, recent arterial thromboembolic events (such as myocardial infarction or stroke), hypercoagulant status, hemophilia; (2) recent use of glucocorticoids, immunosuppressants or autoimmune diseases; (3) exclude patients allergic to anesthetic drugs used in this study; (4) refuse to accept blood products.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma immunoglobulin (lgG, lgA, lgM, lgE);Complement (C3, C4);Lymphocyte subsets (CD3 lymphocyte, CD4 lymphocyte, CD8 lymphocyte and CD4 / CD8 ratio);Inflammatory marker;Routine blood; | — |
Countries
China
Contacts
Public ContactKang Pengde
Department of Orthopedics, West China Hospital, Sichuan University
Outcome results
None listed