The mechanism of non-classical circulatory disorders induced pain after tumor chemotherapy

Mechanism of neutrophil extracellular traps induced microcirculatory disorders involved in chemotherapy-induced peripheral neuropathy.

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900027463

Enrollment

Unknown

Registered

2019-11-14

Start date

2019-11-20

Completion date

Unknown

Last updated

2019-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chemotherapy-induced peripheral neuropathy

Interventions

Healthy group:N/A

Chemotherapy group:N/A

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Male or female, aged >= 18 years; (2) Definitive diagnosis of peripheral neuropathy of chemotherapy, and oxaliplatin in the chemotherapy regimen; (3) Dissatisfaction with pain control, visual pain simulation score (VAS) >= 4 points; (4) no neurological dysfunction; (5) Those who can understand and fill out various rating scales; (6) Voluntary signing of informed consent.

Exclusion criteria

Exclusion criteria: (1) Those with severe heart, lung and kidney dysfunction; (2) those with coagulopathy; (3) cognitive dysfunction or poorly matched patients; (4) Those who are allergic; (5) Patients with contraindications to test drugs (respiratory depression, paralytic ileus, and unconsciousness); (6) Have a history of drug abuse; (7) Patients with mental disorders or those who have been judged by the investigator to be unfit for this test.

Design outcomes

Primary

Measure	Time frame
neutrophil elastase;cf-DNA;Myeloid peroxidase;	—

Countries

China

Contacts

Public ContactChaoyu Wang

Nanjing Medical University

cywang@njmu.edu.cn+86 18602541492

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026