Mild cognitive impairment
Conditions
Interventions
Hyperbaric oxygen treatment group:General drug treatment combined with hyperbaric oxygen therapy
Sponsors
Suzhou Science and Technology City Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Aged 50 and 80 years; 2) Meet the diagnostic criteria for cerebral small vessel disease; 3) MRI findings meet the changing characteristics of LA, with moderate to severe leukoaraiosis (Fazekas grade 2-3) patients as subjects; 4) Check cooperation; 5) Those who signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) History of neurological diseases (such as cerebral infarction, cerebral hemorrhage, multiple sclerosis, Alzheimer's disease), history of psychosis, history of drug and alcohol dependence, carbon monoxide poisoning, and other organic diseases that can cause cognitive decline; 2) White matter lesions caused by diseases of immune diseases, inflammation, tumors, poisoning, and closed brain damage; 3) Angiography confirmed the presence of large blood vessel stenosis in the skull; 4) Contraindications for combined hyperbaric oxygen therapy; 5) Those with serious heart, liver, kidney, hematopoietic diseases and thyroid diseases; 6) Can not perform head MR.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE scale;MoCA scale;HAMD scale;ADL scale;Magnetic resonance examination;Tinetti gait and balance test; | — |
Countries
China
Contacts
Public ContactCai Zenglin
Department of Neurology, Suzhou Science and Technology City Hospital
Outcome results
None listed