Upper Respiratory Tract Infection
Conditions
Interventions
Control Group:no intervention
experimental group:Yogurt containing BL-04
Sponsors
Bright Dairy
Eligibility
Sex/Gender
All
Age
25 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Male or female subjects, 25 to 55 years of age; 2. White collar subject who is in sub-health and low-immunity condition and caught cold 4 to 6 times in the past 1 year; 3. Subject who can understand the objectives and requirements of this study including the potential risk and adverse effect. 4. Subject who voluntarily agrees to join this study and to follow the study design.
Exclusion criteria
Exclusion criteria: 1. Subject who has already been diagnosed as low immunity caused by chronic diseases. 2. Subject who is in the treatment of gastrointestinal diseases. 3. Subject who is having diarrhea currently. 4. Subject who has chronic rhinitis, laryngitis, difficult to breath by thoracic cavity or nose which are similar with upper respiratory tract infection (URTI) symptoms, such as chronic allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD), etc. 5. Subject who is taking analgesic medicines such as Aspirin or Acetaminophen. 6. Subject who took laxatives or other materials which can promote digestion 2 weeks before the initiation of the study. 7. Subject who took milk or other food which contains the prebiotics in the past 10 days before the initiation of the study. 8. Subject who takes medicine which has control or prevention effect on Upper Respiratory Tract Infection (URTI) symptoms for long period, such as antihistamine drugs, antitussive drugs, high-dose Vitamin C, etc. 9. Subject who took medicines which can interfere the immunity in the past 3 months, such as antibiotics. 10. Subject who has been vaccinated with Upper Respiratory Tract Infection (URTI) vaccine in the past 6 months or other vaccines with 15 days. 11. Subject who has alcohol or drug addiction history. 12. Female subject who is pregnant or in lactation or is going to get pregnant in the study intervention period. 13. Subject who has participated in other clinical studies in the past 3 months. 14. Subject who has bad compliance evaluated by PI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of common cold;Incidence of influenza-like illness; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-4;IL-8;IL-10;IFN-?;IgA;IgG;IgM;sIgA;Blood Routine; | — |
Countries
China
Contacts
Public ContactHong Zhang
Respiratory Department, Chaoyang Hospital
Outcome results
None listed